3245 Immunoscintigraphy with antimelanoma monoclonal antibodies in the diagnosis of choroidal melanomas

نویسندگان

  • C. M. Locarno
  • A. N. Balestrazzi
  • G. Fasolino
  • C. Manganelli
  • I. M. Greco
  • M. A. Blasi
  • M. L. Calcagni
  • A. Giordano
چکیده

IMMUNOSCINTIGRAPHY WITH ANTIMELANOMA MONOCLONAL ANTIBODIES IN THE DIAGNOSIS OF CHOROIDAL MELANDMAS. LOCARNO C.M.? BALESTRAZZI AN. ,l FASOLINO G.f MANGANELLI C.l, GRECO I.M.? BLASI M.A.? CALCAGNI M.L.: AN0 GIOROANO A! 'DEPARTMENT OFOPHTHALMOLOGY, CATHOLIC UNIVERSITY OF ROME (I) 'DEPARTMENT OF EXPERIMENTAL MEDICINE, UNIVERSITY OF L'AQUILA (I) 3DEPARTMENT OF OPHTHALMOLOGY, UNIVERSITY OF L'AQUILA (1) 4DEPARTMENT OF NUCLEAR MEDICINE, CATHOLIC UNIVERSITY OF ROME (I)

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Possibilities and limitations of radioimmunoscintigraphy and conventional diagnostic modalities in choroidal melanoma.

A prospective clinical study to assess the value of immunoscintigraphy with a monoclonal antibody (MoAb) against high molecular weight melanoma associated antigen (225.28S) was performed in 43 patients with choroidal melanoma; in six patients with a lesion suspected of being choroidal melanoma, and in seven patients with a benign lesion simulating a choroidal melanoma. The results of immunoscin...

متن کامل

Radioimmunoscintigraphy of ocular melanoma with 99mTc labelled cutaneous melanoma antibody fragments.

The possibility of using radiolabelled monoclonal antibody fragments to image uveal melanomas has been assessed in a pilot study. 99mTc labelled F(ab')2 fragments of MoAb 225.28S raised against cutaneous melanomas were used. Initially 10 patients were imaged. In five patients the clinical findings were typical of uveal melanoma. Immunoscintigraphy was positive in all five cases. In a further fi...

متن کامل

Radioimmunoscintigraphy and immunohistochemistry with melanoma-associated monoclonal antibodies in choroidal melanoma: a comparison of the clinical and immunohistochemical results.

Radioimmunoscintigraphy with monoclonal antibodies (MoAbs) to melanoma associated antigens is a new technique that can be used as an additional test to detect ocular melanomas in clinically difficult cases. Immunoscintigraphy with 99mtechnetium-labelled monoclonal antibody fragments of MoAb 225.28S in 14 patients with melanoma yielded a positive image in only six cases (43%). The expression of ...

متن کامل

Immunoimaging of choroidal melanoma: assessment of its diagnostic accuracy and limitations in 101 cases.

Immunoscintigraphy (IS) was performed on 101 patients with space occupying intraocular lesions including choroidal melanomas (85), choroidal naevi (11), non-melanoma metastases (three), and other melanoma simulating lesions (two). Scintigraphic images with conventional and emission computer tomography techniques were obtained after the intravenous injection of 99mTc-labelled F(ab')2 fragments o...

متن کامل

2254 Immunoscintigraphy with antimelanoma monoclonal antibodies in the diagnosis of choroidal melanomas

Purpose: Lympboprolifcrativc ocular adnexal lesions represent 1 spectrum of disorders which range from reactive lymphoid hyperplasia to malignant lymphoma and include lewas which ared an mddcrminatc nature morphologrccally and immunophenotypically. Futhmnwe cases have been ckcvmented where progresswn from reactix hyperplasia to frank Ippboma has camed. We have applied molecular genetIc te&lques...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Vision Research

دوره 35  شماره 

صفحات  -

تاریخ انتشار 1995